【摘要】 目的了解胰岛素抵抗对血糖的影响和胰岛素抵抗在治疗前后,以及停药后的变化和长期临床缓解的可行性。方法通过测定治疗前后空腹血糖、空腹血浆胰岛素水平,肝、肾功能,甲状腺功能对治疗前后的结果进行分析。结果81例罗格列酮治疗组患者随访调查中,56例患者仅使用罗格列酮治疗,其胰岛素抵抗指数无明显增加(P>0.05);73例胰岛素治疗组患者随访调查中,41例(占56.2%)患者在使用胰岛素强化治疗12周后停药,其胰岛素抵抗指数无明显增加(P>0.05)。结论在初发2型糖尿病患者中,尤其以餐后血糖升高为主、胰岛细胞功能较好的患者中,通过正规治疗,可以得到良好的血糖控制。更多还原

【Abstract】 Objective To study the impact of insulin resistance on blood sugar and the changes of insulin resistance before and after the treatment as well as after the lease of medicine,and the feasibility of long term clinical relief of the insulin resistance on the condition of removing hyperglycemia toxicity.Methods The results were analyzed by means of measuring the fasting blood glucose levels,the fasting plasma insulin levels,the hepatic and renal function,the thyroid function before and after the treatment,the serum glucose levels,the plasma insulin after meals,the indexes such as the ration between waistline and buttocks before and after the treatment.Results In the follow up of 81 patients treated with rosiglitazone,56 patients were treated with rosiglitazone only.As a result, blood glucose showed long-term relief and the insulin resistance index showed no significant increase(P>0.05).Conclusion Therapy can affectively induce serum glucose control in initial type 2 diabetes,especially in patients with increasing blood glucose after meals and with better islet cell function.更多还原