【摘要】 对二氢查尔酮类化合物的分离、分类、生理和药理活性、构效研究、应用以及合成等方面工作作了简要总结.按结构特征对其进行了分类,叙述了其生物来源;并且详细介绍了其化学合成方法,主要有:查尔酮类化合物的加氢还原;苯乙酮与苄基卤化物反应;黄烷酮的转化.二氢查尔酮类化合物有多种生理和药理活性,通过对SGLT-2的抑制作用,对糖尿病具有一定的治疗效果;形成的包合物在生物传感器方面也有一定应用.某些二氢查尔酮类化合物因具有的特殊结构,即7位为新橙皮糖基或葡萄糖基,有特别的甜味,且无毒害,可用于食品添加剂.深入研究其构效关系,寻求简便易行的绿色合成方法,开发生理活性好、应用前景好的该类化合物将是今后二氢查尔酮类化合物的研究方向.更多还原

【Abstract】 This paper reviewed the advance in study on naturally occurring dihydrochalcones,including isolation,distribution,types of structure,biological and pharmacyological activity,synthesis and application.And we classified them according to the characteristics of structure and stated their biological resources.Their chemical synthesis methods mainly includes:chalcone hydrogenation;reaction of acetopenone with benzyl halid;conversion of flavanones.The dihydrochalcones have many biological and pharmacyological activity,including antioxygenation,curing the diabetes by restraining the SGLT-2,turning to the clathrate for biosensor.Some dihydrochalcone can be used as food additive due to their nontoxic special structure,and their special sweet tastes and the further study in this field would be fucus on structure-activity relationship(SAP),green synthesis method and develop new compounds with good biological and pharmacyological activity.更多还原