【摘要】 目的探讨白细胞介素10(IL-10)基因多态性与脑梗死的关系。方法用聚合酶链反应-限制性片段长度多态性技术,对204例脑梗死患者(脑梗死组)和131名健康者(对照组)的IL-10-592C/A、IL-10-819C/T及IL-10-1082G/A,共3个位点的基因多态性进行分析。结果脑梗死组IL-10-1082G/A基因型的分布频率与对照组比较,差异有统计学意义(χ2=11.764,P=0.001);IL-10-1082A等位基因频率为99.5%,对照组为95.8%,两组比较差异有统计学意义(P=0.001);IL-10-592C/A和IL-10-819C/T的基因型分布频率及等位基因频率与对照组比较差异无统计学意义(P>0.05)。结论IL-10-1082G/A基因多态性与脑梗死的发病有一定关系,其中A等位基因频率增高与脑梗死发病有关。更多还原

【Abstract】 Objective To investigate the relationship between interleukin-10(IL-10)gene polymorphisms and cerebral infarction(CI).Methods IL-10-592C/A,-819C/T,-1082G/A gene polymorphisms in 204 patients with CI(CI group)and 131 healthy subjects(control group)were analyzed with polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results There was statistical significance in the distribution frequency of IL-10-1082G/A allele in the CI group as compared with the control group(χ2 = 11.764,P=0.001).The IL-10-1082 A allele frequency was 99.5%,and the control group was 95.8;there was statistical significance between the two groups(P=0.001).There were no statistical significance in genotype distribution frequency of IL-10-592C/A and-819C/T and allele frequency as compared with the control group(P>0.05).Conclusion IL-10-1082G/A gene polymorphisms have certain relationship with CI,in which the increased A allele frequency is associated with the occurrence of CI.更多还原