【摘要】 目的研究EB病毒Rta蛋白在胃癌组织中的表达情况,研究裂解期EB病毒与胃癌的关系。方法采用免疫组织化学方法,应用Rta多克隆抗体检测30例手术切除胃癌组织及其相应癌旁组织中EB病毒BRLF1基因产物Rta蛋白的表达水平与分布情况。结果30例胃癌组织中发现6例R ta蛋白表达阳性,阳性率为20%,相应癌旁组织均为阴性,p=0.031,有显著性差异;Rta蛋白表达阳性率男性多于女性,p=0.024;与病人年龄、病理组织学类型及发生部位之间无明显关系,p=0.196-0.896。结论EB病毒的裂解感染状态与胃癌的发生具有一定相关性,裂解感染期EBV可能在胃癌的发病中起了一定作用。更多还原

【Abstract】 Objective To investigate the expression of Rta protein in gastric carcinoma,and study the relationship between the lytic EBV and gastric carcinoma.Methods Rta in 30 gastrectomy on gastric carcinoma cancer with adjacent non-neoplastic tissue was detected by immunohistologic method.Results 6 gastric carcinoma tissues were positive in Rta protein and no Rta expression detected in.20%of all cases was positive of Rta.The difference between carcinoma and adjacent non-neoplastic tissue was significant p=0.031).Rta expression was significantly different(p=0.024) between male and female,while that was not in age,pathohistological type and locations(p=0.196-0.896).Conclusion Rta expression level in gastric carcinoma is higher than that in their adjacent non-neoplastic tissue.The lytic EBV may play an important role in the pathogenesis of gastric carcinoma.更多还原