【摘要】 目的:探讨弥散加权成像(diffusion weighted imaging,DWI)在前列腺癌诊断与鉴别诊断中的应用价值。方法:50例前列腺疾病患者中前列腺癌19例(年龄56~78岁,平均68岁),BPH31例(年龄47~65岁,平均58岁),另作为对照组的健康志愿者16例(年龄32~57岁,平均46岁)。所有病例均经1.5T高场强超导磁共振成像仪加直肠内线圈后行DWI扫描,所得DWI信号强度值和表观弥散系数(ADC)值行统计学处理。结果:对照组前列腺周围带ADC值为[(170.23±37.39)×10-5mm2/s],中央腺区为[(127.84±17.93)×10-5mm2/s];BPH组为[(175.21±64.86)×10-5mm2/s];前列腺癌组为[(104.23±26.15)×10-5mm2/s]。除对照组前列腺周围带与BPH组比较ADC值没有显著差异外,其余各组两两比较差异均有显著性(P<0.05)。结论:前列腺癌具有特征性DWI表现,与正常前列腺组织和BPHDWI表现差异较大(P<0.05),因此DWI在前列腺癌的诊断与鉴别诊断中具有较高的临床应用价值。更多还原

【Abstract】 Objective: To explore the diagnostic and differential value of diffusion weighted imaging(DWI) for prostate cancer. Methods: Included in the study were 50 patients with prostatic diseases,including 19 cases of prostate cancer(PCa) and 31 cases of benign prostatic hyperplasia(BPH),and another 16 healthy volunteers were recruited as controls.All underwent DWI sequence on a 1.5T superconducting MRI system with an endorectal coil.The results from DWIs and apparent diffusion coefficient(ADC) maps were treated statistically. Results: The mean ADC value of the prostatic peripheral zone and the prostatic central gland of the 16 healthy volunteers were(170.23 ± 37.39) × 10-5 mm2 / s and(127.84 ± 17.93) × 10-5 mm2 / s,while those of the 31 BPH cases and 19 PCa cases were(175.21 ± 64.86) × 10-5 mm2 / s and(104.23 ± 26.15) × 10-5 mm2 / s,respectively.There were significant differences in the tissue types between any two groups after the treatment of one-way ANOVA,except between the groups of the peripheral zone and BPH.Conclusion: PCa shows specific DWI features that could be distinguished from those of the normal prostatic tissues and BPH.Therefore,DWI has an important clinical application value in the diagnosis and differentiation of PCa.更多还原