【摘要】 目的:观察比较结合雌激素片(试验组)与结合雌激素倍美力片(对照组)治疗绝经期综合征的疗效和安全性。方法:选取60例符合诊疗标准的患者随机分成试验组和对照组,每日服结合试验或对照药物1片,28天为1周期,第15～28天均添加安宫黄体酮片每日4mg,通过随机开放平行对照方法对两组潮热症状评分,Kupperman评分、血清E2水平、血脂的变化及不良反应发生情况比较。结果:两组治疗后,潮热症状评分及Kupperman评分均明显下降,血清雌二醇、甘油三酯(TG)和高密度脂蛋白(HDL-C)均升高,低密度脂蛋白(LDL-C)降低,组内比较(P<0.001),差异有统计学意义。组间等效性检验比较(P>0.05),无显著性差异。不良反应两组之间比较(P>0.05),无显著差异。结论:国产结合雌激素片和倍美力一样能有效、安全地治疗妇女绝经期综合征。更多还原

【Abstract】 Objective:To compare the efficacy and the safety of conjugated estrogen(CE) in the treatment of menopausal with conjugated equine estrogen(Premarin). Methods:According to the standards ,a total of 60 patients were randomly divided into 2 groups:CE group and Premarin group,a period of 28 days,and from 15 to 28 days plus medroxyprogesterone(MPA) 4 mg Daily.Treatment lasted for 3 periods. This randomly publicly parallel was adopted to compare the hot flashes symptom scores,serum level of estradiol,Kupperman measurement Index and serum lipid. Results:The scores of menopausal symptom,hot flash scores and the serum level of estradiol ascent. TG、HDL-C ascented and LDL-C were reduced after treatment with CE or Premarin(P < 0.001),No significant differences were discovered between the two groups through equivalence margin(P > 0.05). There are no significant differences between the two groups on side effect(P > 0.05). Conclusion:CE is safe and effective in treatment of menopausal symptoms.更多还原