【摘要】 研究不同作用时间和不同暴露浓度下阿特拉津对鲫鱼肝脏、肾脏和肌肉谷胱甘肽-S转移酶(GSTs)活性的影响。结果表明:阿特拉津对鲫鱼各个组织器官GSTs活性产生较强的影响。长期暴露下(24 d),阿特拉津对鲫鱼肝脏和肌肉GSTs活性基本表现为诱导作用,最大诱导率为110.81%和32.54%,且分别在0.15.0和1.010.0 mg.L-1质量浓度范围内存在剂量-效应关系;对鲫鱼肾脏GSTs活性具有抑制作用,最大抑制率为14.42%,且在所设质量浓度(010 mg.L-1)范围内均表现出剂量-效应关系。在10.0 mg.L-1质量浓度暴露下第6—14天内,阿特拉津与鲫鱼肝脏及肌肉GSTs活性间存在时间-效应关系;其他情况下,任何组织器官在试验期间均未表现出时间-效应关系。更多还原

【Abstract】 Atrazine is one of the most widely used herbicides in China and worldwide.Being highly persistent,it exists for long in surface and ground waterbodies,threatening nontarget organisms,such as fish,and contaminating drinking water for human beings.An experiment was conducted on Carassius auratus to study effect of atrazine on glutathione S-transferases（GSTs） activity.Groups of fish were exposed to atrazine varying in concentration,i.e.0,0.1,0.5,1.0,5.0 and 10.0 mg·L^-1,respectively.The GSTs activities in liver,kidney and muscle of fish exposed to 1.0 and 10.0 mg·L^-1 were measured after Day 3,6,10,14,19 and 24,respectively,to study time-response relationship between atrazine and GSTs activities in these organs.At the end of the experiment（24 days）,GSTs activities in the three organs of fish in all treatments were evaluated to explore dose-response relationships between atrazine and SOD activities in these organs.Results indicate that atrazine had strong influences on GSTs activities in the three organs;long exposure（24 days） to atrazine induced activities of GSTs in liver and muscle,with a maximum rate being 110.81% and 32.54%,respectively;and their dose-response relationship was significant,when the concentration ranged from 0.1 to 5.0 mg·L^-1 and from 1.0 to 10.0 mg·L^-1,respectively.Long exposure（24 days）,however,inhibited renal GSTs activities,with a maximum rate being 14.42%,and their dose-response relationship was distinct in all the treatments in the experiment.When the fish was exposed to atrazine,10.0 mg·L^-1 in concentration,on Day 6-14,the time-response relationships existed between atrazine and activities of GSTs in liver and muscle,but did not in any organs in any other treatments.更多还原