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HLA-A、-B基因多态性与流行性出血热的相关性
Association of the polymorphism of HLA-A,-B alleles with epidemic hemorrhagic fever
【摘要】 目的探讨HLA-A、-B等位基因与流行性出血热的相关性。方法采用聚合酶链反应-序列特异性引物(PCR-SSP)技术,检测流行性出血热患者的HLA-A、-B等位基因。结果与50例正常对照组比较,在50例出血热患者中HLA-A*31的基因频率明显增高,经统计学检测,两组差别具有显著性(RR=14.8,χ2=4.388,P=0.036);患者组中HLA-B*40等位基因的基因频率显著低于健康对照组,两者之间差异具有显著性(RR=0.42,χ2=3.895,P=0.048)。结论HLA-A*31、-B*40等位基因与流行性出血热具有相关性,A*31可能是其易感基因,B*40可能是保护基因。
【Abstract】 Objective To analyze the association between HLA-A,B alleles’ polymorphism and epidemic hemorrhagic fever(EHF).Methods HLA-A,B typing of 50 patients with EHF were investigated by polymerase chain reaction-sequence specific primer(PCR-SSP).The frequencies of HLA-A,B of the patients were detected and compared with those of 50 normal controls.Results The frequency of HLA-A*31 in patient group was significantly higher than that in control group(RR=14.8,χ2=4.388,P=0.036),but the frequency of HLA-B*40 was strikingly lower(RR=0.42,χ2=3.895,P=0.048).Conclusion HLA-A,-B alleles are correlated to the incidence of EHF;HLA-A*31 may contribute to the genetic susceptibility to EHF while HLA-B*40 may contribute to genetic resistant to EHF.
- 【文献出处】 免疫学杂志 ,Immunological Journal , 编辑部邮箱 ,2007年04期
- 【分类号】R512.8
- 【被引频次】3
- 【下载频次】86