【摘要】 目的研究哮喘大鼠肺组织MUC5AC黏蛋白的分布及红霉素对其影响。方法36只清洁级SD大鼠随机分成对照组、哮喘组、和红霉素治疗组,采用免疫组化SP法和计算机图象分析检测肺组织中MUC5AC黏蛋白的分布。结果哮喘组MUC5AC黏蛋白表达(2.4167±0.6686)较对照组(0.5833±0.7930)明显增加,红霉素治疗组(1.1667±0.9374)降低,和哮喘组相比有统计学意义。结论反复抗原刺激引起气道过敏性炎症,导致气道黏蛋白的大量产生,加重哮喘气道炎症和气道阻塞,红霉素可下调MUC5AC黏蛋白,对气道黏蛋白高分泌有明显的治疗作用。更多还原

【Abstract】 Objective To investigate the distribution of protein MUC5AC in the lungs of asthmatic SD rats and the effects of erythromycin. Methods Thirty-six SD rats were randomly divided into control group,asthmatic group,and erythromycin-treated group,and each immunohistochemical SP method and computer image analysis were used in this study. Results Protein MUC5AC(2.4167±0.6686)in asthmatic group were significantly higher than those in control group(0.5833±0.7930) and reduced (1.1667±0.9374) after treatment with erythromycin. Conclusion Repeated antigen challenges,which cause the allergic inflammation of airways,may result in mucin hypersecretion;this may be involved in the persistence and exacerbation of airway inflammation and obstruction in asthma.Erythromycin substantially downregulates protein MUC5AC,which may have potential therapeutic role in mucin overproduction of airway.更多还原