CD44_V6基质金属蛋白酶及其抑制因子在子宫内膜增殖症中的表达及意义

【摘要】 目的研究子宫内膜增殖症组织中CD44V6、基质金属蛋白酶MMP-2、MMP-9及其抑制物:组织金属蛋白酶抑制剂TIMP-1、TIMP-2的表达,探讨它们在子宫内膜不典型增生诊断、治疗中的价值。方法应用免疫组化二步法对子宫内膜增殖组及对照组的子宫内膜组织中CD44V6、MMP-2、MMP-9、TIMP-1、TIMP-2的表达进行研究、分析。子宫内膜增殖组共92例,其中单纯性增生24例,复杂性增生26例,不典型增生42例;正常增生期子宫内膜共23例。结果在不同的病理分型中随组织细胞异型性的增加,CD44V6、MMP-2、MMP-9、TIMP-1、TIMP-2阳性表达率均增加。对不典型增生组中该五指标的阳性表达进行Spearman相关性分析,它们的阳性表达强度之间存在正相关。结论推测它们可能相互作用共同促进细胞过度增殖,从而导致肿瘤的形成和进展。更多还原

【Abstract】 Objective To analyze the expression of CD44_V6, MMP-2,MMP-9 and their inhibitor TIMP-1,TIMP-2 in tissue of endometrial hyperplasia, then to investigate their clinical value in diagnose and treatment in atypical hyperplasia of endometrium （AH）. Methods Immunohistochemistry technique was used to detect CD 44 V6, MMP-2, MMP-9, TIMP-1 and TIMP-2 expression in EH group and control group .In EH group ,there were 24 cases of single hyperplasia ,26 cases of complex hyperplasia and and 42 cases of atypical hyperplasia . Results The positive rate of CD 44 V6, MMP-2, MMP-9, TIMP-1, TIMP-2 were different in various types of EH. The expression of CD 44 V6、MMP-2、MMP-9、TIMP-1、TIMP-2 had a striking positive correlation with the heteromorphism in cells and tissue of AH using Spearman correlation analysis . Conclusion CD 44 V6、MMP-2、MMP-9、TIMP-1、TIMP-2 might work together play an important role in Endometrial Hyperplasia ,which might be related with tumor formation .更多还原