【摘要】 提出了测定药物利眠宁的二阶导数单扫描示波极谱方法。在0.12 mol.L-1氨水-NH4Cl(pH 10.2±0.1)的缓冲溶液中,利眠宁于-1.25 V处产生一极谱还原波,二阶导数峰电流与其浓度在1.6×10-7~2.4×10-5mol.L-1范围内呈线性关系(r=0.999 3,n=8),检出限为2.0×10-8mol.L-1。测定了片剂中利眠宁的含量。测得结果与HPLC法的结果一致,其RSD值为0.56%,回收率结果在96.4%~102.1%之间,讨论了利眠宁的电化学行为。更多还原

【Abstract】 Single-sweeping oscillopolarography was applied to the determination of chlordiazepoxide.A polarographic reductive wave of chlordiazepoxide was observed at-1.25 V in an ammoniacal buffer medium of pH 10.2±0.1.Linearity was kept between the 2nd derivative of peak current(I″p) and the concentration of chlordiazepoxide and in the range of 1.6×10-7-2.4×10-5mol·L-1(r=0.999 3,n=8),with a detection limit of 2.0×10-8mol·L-1.In its application to the analysis of chlordiazepoxide tablets,results obtained were in consistency with the results found by HPLC.Value of RSD′s(n=8) of this method was found to be 0.56%.Recovery test was performed and results obtained were in the range of 96.4%-102.1%.A study on the electrochemical behavior of chlordiazepoxide was also made and a brief discussion was given.更多还原