【摘要】 [目的]探讨我国汉族人群血管紧张素转换酶(ACE)基因多态性与原发性高血压(EH)的关系。[方法]应用Meta分析方法对国内有关汉族人群共计1678名原发性高血压患者和1630名正常对照的ACE基因多态性与原发性高血压关系的15个研究结果进行综合定量分析。用随机效应模型(D-L法),计算合并比值比OR及其95%的可信区间(95%CI)。[结果]基因型DD(/ID,II)、等位基因(D/I)分布的合并OR分别为1.78(95%CI:1.30~2.78)和1.24(95%CI:1.03~1.49)。[结论]我国汉族人群中带有DD基因型以及D对位基因的个体容易患原发性高血压。更多还原

【Abstract】 [Objective] To study the relations between angiotensin converting enzyme(ACE)gene polymorphism and essential hypertension in the Han nationality in China. [Methods] 15 separated studies on the relation between ACE gene polymorphism and essential hypertension in China were analyzed by Meta-analysis. Random effect model was selected to calculate the pooled odds ratio(ORs)and its corresponding 95% confidence interva(l95% CI). [Results] The pooled OR for frequency of genotypes and allele were 1.78(95%CI:1.30~2.78)and 1.24(95%CI:1.03~1.49)respectively. [Conclusion] The DD genotype and D allele of ACE gene may be risk factors for essential hypertension.更多还原