【摘要】 目的探讨急性髓细胞白血病(AML)细胞尿激酶型纤溶酶原激活物受体CD87(uPAR)的表达及其在诊断急性白血病分型、指导预测预后方面的意义。方法应用流式细胞术(FCM)检测了41例初治的AML患者(包括M12例,M217例,M45例,M517例),应用t检验及χ2检验分析CD87阳性与CD87阴性患者在临床表现、染色体异常及完全缓解率间的差异,应用logistic回归分析影响患者完全缓解的具有统计学意义的因素。结果41例AML患者,26例CD87阳性表达,CD87阳性与CD87阴性AML患者比较肝肿大比例分别为73%与40%,(P<0.05),而淋巴结肿大、脾肿大比例无明显的统计学意义(P>0.05);出血倾向比例分别为77%与46%,(P<0.05);染色体异常的比例分别为73%与40%,(P<0.05);1疗程完全缓解率分别为40%与73%,(P<0.05),CD87阳性是导致患者完全缓解率低的独立因素。结论CD87表达有助于AML的诊断,CD87阳性与疾病进展包括浸润、出血、缓解率低等不良预后相关。更多还原

【Abstract】 Objective:To explore the expression of urokinase-type plasminogen activator (CD87) on acute myeloid leukemia (AML) in adults and its clinical significance in leukemia diagnosis, typing and predicting prognosis.Method:Flow cytometric quantitative analysis of expression levels for CD87 was performed on fresh blast cells from patients with acute myeloid leukaemia (AML, n=41) using CD87 monoclonal antibodies. The difference between CD87 positive and negative patients in clinical features、chromosome abnormalities and CR rate was analyzed using t-test and chi-square test. The factors which influence the CR rate were analyzed using logistic regression.Result:63%(26/41) of AML patients were CD87 positive. In CD87 positive and negative groups of AML, the percentages of hepatomegaly were 73% and 40%( P < 0.05 ), while the percentages of lymphadenovarix and splenomegaly had no statiatical differience. The percentages of bleeding tendency were 77% and 46% ( P < 0.05 ), the percentages of chromosome abnormalities were 73% and 40%( P < 0.05 ), the percentages of complete remission rate were 40% and 73%( P < 0.05 ). CD87 is independent factor which influence the CR rate using logistic regression.Conclusion:CD87 might be used as one of the markers for leukemia diagnosis, typing and predicting worse prognosis.更多还原