【摘要】 目的研究幽门螺杆菌(Hp)感染和fas、fasL、c-myc、VEGF表达与胃癌浸润转移的关系,探讨其可能作用机制。方法采用快速尿素酶试验及病理切片Giemsa染色检测Hp感染,免疫组化检测fas、fasL、c-myc、VEGF表达。结果Hp阳性组中VEGF、c-myc表达均高于Hp阴性组。VEGF表达率越高,分期越晚。结论Hp作为致癌物质,可能通过VEGF、c-myc参与胃癌发生发展,VEGF对胃癌浸润转移具有一定作用。更多还原

【Abstract】 Objective To investigate helicobacter pylori(Hp) infection and expressions of fas,fasL,c-myc,VEGF in gastric carcinoma,and their associations with invasion and metastasis of gastric cancer.Methods Hp infection was assessed by using the rapid urease rest and section-staining.Immunohistochemical staining was used to detect the expressions of fas,fasL,c-myc,VEGF.Results The expression rates of c-myc,VEGF in Hp positive group were higher than those in Hp negative group.The higher VEGF expressed,the later the stage lay.Conclusion Hp might act as a tumor promoter during the genesis of gastric carcinoma by influencing the expressions of c-myc,VEGF.There are some relationships between the expression of VEGF and the invasion and metastasis of gastric cancer.更多还原