【摘要】 目的探讨老年高血压患者静息心率(RHR)与靶器官损害的关系及其临床意义。方法150例老年高血压患者,按RHR水平分为<65次/min组(A组),52例;≥65~<80次/min组(B组),51例;≥80次/min组(C组),47例。对入选患者分别行超声心动图、颈动脉超声及头颅CT或MRI检查,测定RHR、血压、血糖、血脂、体质指数、肌酐、尿素氮、尿酸,进行分组研究。结果随着RHR水平的增加,收缩压、舒张压、脉压、体质指数、总胆固醇、低密度脂蛋白胆固醇、空腹血糖、尿酸有上升趋势;颈动脉内膜厚度、左室肥厚病例数增加;左室重量指数、临床神经功能缺损程度升高,左室射血分数、日常生活能力下降。各组间比较差异有统计学意义(P<0.05或P<0.01)。结论老年高血压患者随RHR的增高,发生心脑血管损害的机会也在增加,RHR可能是心脑血管疾病发生的危险因素及预后的预测因子。更多还原

【Abstract】 Objective:To investigate the relationship between the resting heart rate (RHR) and the target organ damage in senile patients with hypertension and its clinical significance. Method:According to the level of RHR, 150 senile patients with hypertension were divided into three groups: A group(n=52 ), RHR<65 beats per minute; B group(n=51 ), 65≤RHR<80 beats per minute and C group (n=47), RHR ≥ 80 beats per minute. Result:Differences with statistical significance ( P <0.05 or P <0.01) were found in comparisons of each measured index among three groups. When RHR increased, ①systolic blood pressure, diastolic blood pressure, pulse pressure, body mass index, total cholesterol, low density lipoprotein, blood-fasting sugar and acidum uricum increased;②the number of the cases of thickness of endomembrane of arteria carotis and left ventricular hypertrophy increased;③left ventricular mass index and the level of clinical neurologic impairment increased;④left ventricular ejection fraction and activity of daily living decreased. Conclusion:Along with the increase of RHR in senile patients with hypentension, the chance to induce cardio/cerebrovascular diseaces increases. RHR might be the risk factor of cardio-/cerebrovascular diseases and an important prognostic predictor.更多还原