【摘要】 目的以光吸收值≥0.25u的时间百分比(total time percent with absorbance value≥0.25u,AV0.25)作为诊断标准,评价十二指肠内胆红素光吸收值监测在胆道闭锁(biliary atresia,BA)诊断中的应用价值。方法分别以AV0.25=0及AV0.25>0作为BA及婴儿肝炎综合征(infantile hepatitis syndrome,IHS)的诊断标准,对23例BA患儿(男15例,女8例,年龄2~17周,平均6.5周)及42例IHS患儿(男29例,女13例,年龄3~18周,平均8.4周)进行诊断试验,评价其在BA早期诊断中的应用价值。结果胆红素光吸收值监测在BA诊断中的准确率、特异度、阳性预测值、阴性预测值及正确诊断指数分别为95%,93%,88%,100%,0.93。结论以AV0.25=0作为诊断标准的十二指肠内胆红素光吸收值监测为BA提供了一种新的、准确的诊断方法。更多还原

【Abstract】 Objective To evaluate the reliability of ambulatory bilirubin monitoring in the diagnosis of biliary atresia (BA) when total time percent with absorbance value ≥0.25 U (AV0.25) was selected as criteria to BA.Methods When criteria to BA and infantile hepatitis syndrome (IHS) were set as AV0.25=0 and AV0.25>0,diagnostic testing was done in BA group (11 males and 6 females;age 2～16 weeks,average 6.5 weeks) and IHS group (29 males and 13 females;age 3～18 weeks,average 8.4 weeks).Results The accuracy,specificity and positive predictive value,negative predictive value and Youden’s index of this method were 95%,93%,88%,100% and 0.93 respectively.Conclusion Ambulatory bilirubin monitoring with the criteria of AV0.25=0 provides a new and reliable diagnostic method to BA.更多还原