【摘要】 目的:探讨乳腺癌患者手术前后血清CA153、CA125和CEA水平的变化。方法:应用化学发光免疫分析法(CLIA)检测168例乳腺癌(Ⅰ+Ⅱ期125例,Ⅲ+Ⅳ期43例)患者血清CA153、CA125和CEA含量,并与132例非肿瘤患者作比较。结果:乳腺癌患者手术治疗前血清CA153、CA125和CEA含量非常显著地高于非肿瘤患者组(P<0.01);三者联合检测较单一检测阳性率明显增高(P<0.01)。Ⅰ+Ⅱ期患者手术后3个月CA153、CA125和CEA水平下降(P<0.05),与非肿瘤患者组比较无显著性差异(P>0.05);Ⅲ+Ⅳ期患者手术后3个月CA153、CA125和CEA水平明显下降(P<0.05),但仍高于非肿瘤患者组(P<0.05)。结论:检测乳腺癌患者血清CA153、CA125和CEA含量对临床诊断和预后观察具有重要的临床价值。更多还原

【Abstract】 Objective:To investigate changes of serum CA153,CA125 and CEA levels after operation in patients with breast cancer.Methods:Serum CA153,CA125 and CEA levels were measured by CLIA in 168 patients with breast cancer(I or Ⅱ 125,Ⅲ or Ⅳ 43) both before and 3 months after operation.While 132 controls also underwent these detection.Results:Before operation,in the patients the serum CA153,CA125 and CEA levels were significantly higher than those in the controls(P<0.01).The positive rate of Combined determination of serum CA153,CA125,CEA was higher than that in single determination(P<0.01).Three months after operation,the serum(ⅠorⅡ) CA153,CA125 and CEA levels dropped markedly(P<0.05)and were not significantly different from those in controls(P>0.05).Three months after operation the serum(Ⅲ or Ⅳ)CA153,CA125,CEA levels dropped markedly(P<0.05),but were still higher than those in controls(P<0.05).Conclusion: Detection of serum CA153,CA125 and CEA levels is valuable for the diagnosis and outcome prediction in patients with breast cancer.更多还原