【摘要】 目的探讨原发性中枢神经系统淋巴瘤(PCNSL)的诊断及治疗措施。方法回顾性分析18例PCNSL的临床、影像学特征及治疗效果。结果18例患者均经手术病理确诊;15例患者行手术治疗和(或)术后放疗和(或)常规CHOP方案化疗,生存期为3~18个月;3例患者手术确诊后使用大剂量甲氨蝶呤(MTX)为主的方案化疗及鞘内注射药物等治疗,生存期均大于36个月。结论PCNSL临床症状及影像学无特征性,诊断困难,易误诊;手术治疗、术后放疗及常规CHOP方案化疗的疗效欠佳,采用易通过血脑屏障药物治疗可取得一定的疗效。更多还原

【Abstract】 Objective To evaluate the diagnosis and treatment methods of primary central nervous system lymphoma(PCNSL).Methods The clinical characteristics, imaging features and therapeutic outcome in 18 cases of PCNSL were analyzed retrospectively.Results The diagnosis was confirmed by the pathology study in all the subjects.15 patients received operation and/or radiotherapy and/or CHOP regime chemotherapy with the survival time ranging from 3 months to 18 months.Whereas,the survival time exceeded 36 months in the rest 3 patients who were treated with high-dose methotrexate (MTX) chemotherapy plus intrathecal injection.Conclusion PCNSL usually didn’t show the characteristic changes in clinical manifestation or imaging scanning,resulting in difficult establishment of the diagnosis and sometimes misdiagnosis.The therapeutic outcome was not satisfying with surgical removal of the tumors,and/or radiotherapy and/or regular chemotherapy,but improved with some chemotherapic drugs which are able to penetrate the blood-brain barrier.更多还原