【摘要】 本研究检测了64例慢性丙型肝炎(CHC)患者的血清HCV RNA基因型、IFN-γ和IL-4水平、HCV-RNA含量以及ALT水平。结果显示CHC患者血清IFN-γ水平在1b型的患者显著低于2 a型(P<0.05),与病毒载量、ALT水平等均无显著性相关(均为P>0.05)。在同一基因型中,血清IL-4、IFN-γ水平与ALT水平、病毒载量亦无相关(P>0.05)。在同一基因型中,血清IL-4、IFN-γ水平与ALT水平、病毒载量亦无相关(P>0.05):在诸多抗病毒影响因素中,病毒基因型在血清IFN-γ水平上具有差别,提示1b型较其他基因型为低的IFN-γ水平可能是该型更易发生HCV持续感染的因素之一。更多还原

【Abstract】 The genotype of hepatitis C virus,the levels of serum IFN-γ and IL-4,serum viral load and the level of ALT level were determined in the patients suffered from chronic hepatitis C.The level of serum IFN-γ from patients with genotype 1b was significantly lower than that from genotype 2a(P<0.05).There was no correlation between the levels of serum IFN-γ and IL-4 and age,gender,serum ALT level or HCV RNA level(P>0.05).And just in patients with the same genotype,there was no correlation between the levels of serum IFN-γ and IL-4 and the serum ALT level or HCV RNA level(P>0.05).The low level of IFN-γ in the patients with genotype 1b might be a factor on sustained infection to hepatitis C virus.更多还原