【摘要】 目的观察和分析含加替沙星方案治疗耐药肺结核的疗效。方法对2004年7月~2006年12月期间收治资料完整的120例耐药肺结核病例,分为治疗组60例,对照组60例。治疗组应用含加替沙星联合抗结核化学药物,对照组应用含环丙沙星的抗结核化学药物。两组其他抗结核药物组成相同。疗程1年。结果两组病例疗程结束时,痰结核菌转阴率治疗组93.3%,明显高于对照组85.0%(P<0.05)。治疗组病灶吸收和空洞闭合率分别为98.4%和65.6%;对照组病灶吸收率和空洞闭合率分别为75.0%和45.5%(P<0.05)。结论在痰菌阴转、病灶吸收、空洞闭合方面含加替沙星方案均明显优于含环丙沙星方案。并且在完成强化期治疗时,含加替沙星方案痰菌阴转情况明显优于含环丙沙星方案。更多还原

【Abstract】 Objective To observe the effect of gatifloxacin in the treatment for multi-drug resistant tuberculosis(MDR-TB) patients.Methods.120 MDR-TB patients who were admitted to hospital and who had completed clinical data for the treatment were included for the study.The duration for the treatment was between July 2004 and December 2006.The patients were divided into therapeutic group(n=60) and control group(n=60).The patients in the therapeutic group were treated with using gatifloxacin for a consecutive one-year period while the patients in the control group were treated with using ciprofioxacin also for 12 months.The other medications used for both groups were the same.Results At the end of the treatment period,the therapeutic group had achieved better clinical effects than the control groups in sputum positive-turned-negative rate(93.3% and 85.5%,respectively for the two groups;P<0.05) in lesion absorption rates(98.4% and 70.0% respectively for the groups;P<0.05) and in cavity closure rate(65.6% and 45.5% respectively for the groups: P<0.05).Conclusion Gatifloxacin has better clinical effect than ciprofioxacin in the treatment of multi-drug resistant tuberculosis patients.更多还原