【摘要】 目的探讨胸腔内注入顺铂(DDP)联合滑石粉治疗恶性胸腔积液的疗效。方法病理确诊的恶性胸腔积液58例,经胸腔插管引流术排除胸水后,随机分为二组,开始均胸腔内注入80mg顺铂,治疗组(A组,30例)1周后重复一次,并注入3%滑石粉混悬液100ml;对照组(B组,28例)1周后使重复一次,观察疗效、生活质量、生存率及毒副反应。结果治疗组总有效率80%,较对照组46%,差异有显著性(P<0.01)。治疗组0.5、1年的生存率分别高于对照组,差异有显著性。结论胸腔内联合注入DDP和滑石粉治疗恶性胸腔积液是一种有效的、经济的、副反应少的方法。更多还原

【Abstract】 Objective To investigate the therapeutic effects of cisplatin and talc powder to malignant pleural effusion by injection with thoracic drainage tube. Methods There were fifty-eight patients with final pathologic diagnosis of malignant pleural effusion. After thoracic drainage was made thoroughly, they were randomly separated to treatment group and control group. First, each case was respectively injected with cisplatin 80 mg into pleural cavity. 1 week later, each patient in the treatment group was injected with 3% talc powder suspl 100 ml and cisplatin 80 mg. The control group was merely repeated with cisplatin 80 mg. The therapeutic effects, quality of life, survival rate, and side effect were surveyed. Results Overall response rate for the treatment group had an significant advantage than that in the controls (80% to 46% P<0.01). The quality of life in the treatment group was also better. The survival rate!of treatment group was also significantly higher than that in the control group in half a year and one year later (97% to 68%, and 57% to 46%) respectively for the treatment and control groups: P<0.05). Conclusion Draining the fluid completely followed by intracavity injection of cisplatin and talc powder is an effective and economic treatment method with slight side effect for malignant pleural effusion.更多还原