【摘要】 目的探讨尿毒症的微炎症状态及其与胰岛素抵抗的关系。方法测定55例尿毒症维持性血液透析(maintenance hemodialysis,MHD)患者及30例正常人慢性炎症指标血C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α),同时检测空腹胰岛素(FINS)、空腹血糖(FBS)、血脂及肾功能等指标,计算稳态模型胰岛素抵抗指数(Homa-IR)作为胰岛素抵抗指标。结果MHD组血CRP、IL-6、TNF-α分别为(5.08±2.53)mg/L、(127.6±104.1)ng/L、(1.63±0.64)μg/L,均高于对照组且差异有统计学意义(P<0.05～0.01)。MHD患者血CRP与Homa-IR、FINS、血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)呈正相关(P<0.05～0.01)。结论MHD患者存在微炎症状态,炎症与胰岛素抵抗密切相关。更多还原

【Abstract】 Objective To explore the correlation of microinflammatory state with insulin resistance in maintenance hemodialysis (MHD) patients.Methods The chronic inflammatory indices including serum C-reactive protein(CRP),interleukin-6 (IL-6),tumor necrosis factor-α(TNF-α) were measured in 55 MHD patients and 30 normal controls.Simultaneously,their fasting insulin(FINS),fasting blood sugar(FBS),lipid profile and renal function indices were also determined.Insulin resistance was evaluated using Homa-IR.Results The serum CRP,IL-6,TNF-α levels were (5.08±2.53) mg/L,(127.6±104.1) ng/L,(1.63±0.64) μg/L respectively in MHD group,all of which were higher significantly than those in control group(P<0.05-0.01).CRP positively correlated with Homa-IR,FINS,TC,TG,LDL-C(P<0.05-0.01) in MHD group.Conclusion There is microinflammatory state in MHD patients and microinflammatory state may closely correlate to insulin resistance.更多还原