【摘要】 目的:观察圆窗内置管微泵灌注地塞米松治疗难治性突发性感音神经性聋(突聋)的疗效。方法:13例常规方法治疗4.8周无效的突聋患者,作外耳道皮瓣,圆窗置管经微泵灌注地塞米松,每次2.5mg,维持1h,每天2次,连续给药1周。用药期间观察记录听力改变、耳鸣和眩晕等情况。结果:13例患者治疗完成后1个月纯音测听检查:显效2例,0.25~4.00kHz听阈平均提高30.5dB;有效3例,平均提高16.7dB;无效8例,有效率38.5%(5/13)。结论:圆窗置管微泵灌注地塞米松治疗突聋的方法,能保证药物持续泵入和高浓度作用于内耳,优于鼓膜穿刺注药;操作稍复杂,但创伤小,耗费不高,为常规方法治疗无效的突聋患者提供了再次治疗获效的机会。更多还原

【Abstract】 Objective:To investigate the efficacy of round window catheter placement with dexamethasone perfusion for 13 patients with intractable sudden sensorineural hearing loss (SSNHL).Method:Dexamethasone (2.5 mg) was perfused transtympanically through round window catheter by Micro-infusion pump. The perfusion was taken twice a day and continued for an hour each time, for a total of 7 days.Result:Thirteen patients have been followed up for 1 month. Five of them (38.5%) were demonstrated a 17~54 dB improvement in pure-tone threshold average (PTA). The other 8 patients (61.5%) had no effect.Conclusion:Round window catheter placement with dexamethasone perfusion is a cost-effective and useful treatment for SSNHL patients who had no effect through conventional therapy, although hearing thresholds of these patients had hardly improved to normal levels.更多还原