【摘要】 目的:评估根治性放疗加外科挽救手术或手术加放疗综合治疗晚期扁桃体癌的临床疗效。方法:回顾性分析48例晚期扁桃体癌患者的临床资料,其中根治性放疗加外科挽救手术21例(A组),手术加放疗27例(B组)。总结2组治疗效果,并应用华盛顿医科大学生活质量表调查患者生活质量。结果:A组的5年生存率为42.9%,B组为45.8%(P>0.05)。2种治疗方式均导致不同程度的生活质量降低,46例患者(2例失访)生活质量平均分661.00±98.52,A组得分696.09±90.70,B组得分631.52±96.74(P<0.05)。结论:根治性放疗加外科挽救手术与手术加放疗治疗晚期扁桃体癌的5年生存率相似。前者使部分晚期扁桃体癌患者避免了联合根治术,功能损害少,提高了患者治疗后的生活质量。更多还原

【Abstract】 Objective:To evaluate the treatment of advanced tonsillar carcinoma by radiotherapy plus salvage surgery(R+S) or surgery coupling with postoperative radiotherapy(S+R). Method:Clinical data of 48 patients with advanced tonsillar carcinoma who were treated in The 2nd Affiliated Hospital of Sun Yat-sen University from June 1996 to June 2004 was retrospectively analyzed. The patients were divided into R+S group (group A, 21cases) and S+R group (group B, 27cases). Treatment outcomes were compared between these two groups. The QOL (quality of life) scale of Washington University (UW-QOL) was used to investigate the patient’s quality of life. Result:The 5-year survival rates were 42.9% in group A and 45.8% in group B, there was no significant statistical difference between the two groups (P<0.05). Both the two treatment modalities could reduce the QOL in some degree. The average QOL score of 46 patients was 661.00±98.52 , group A was 696.09+90.70, while group B was 631.52±96.74, there was a significant statistical difference between the two groups (P<0.05). Conclusion:The two treatment modalities reached similar survivals. However, compared with the S+R, some patients who accepted treatment of R+S could avoid composite resection, reduce functional lesion and improve the QOL.更多还原