【摘要】 目的探讨二维超声、多普勒超声及超声-生理学指标对颈动脉粥样硬化的评价。方法选取经临床确诊的颈动脉粥样硬化患者49例和正常人35例,分为观察组与对照组,进行颈总动脉(CCA)血流动力学、内-中膜厚度(IMT)及血管超声-生理学指标对照分析,确定评价颈动脉粥样硬化的可行性指标。结果①观察组左右侧CCA主干和分叉部IMT较对照组显著增厚(P<0.01);②观察组收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)、平均血流速度(MV)均降低,与对照组比较差异有统计学意义(P<0.05);③观察组的扩张系数(Dc)和顺应系数(Cc)较对照组均减低,扩张系数两组比较差异有统计学意义(P<0.05);④颈动脉主干IMT与PSV、EDV、MV、Dc之间成负相关,与相应脉压(PP)、收缩压(SBP)、CCA的收缩期内径(Ds)、舒张期内径(Dd)、动脉壁僵硬度(wall stiffness)β之间成正相关。结论高频超声检查IMT、血流动力学参数PSV、EDV、MV降低,收缩期峰值血流速度与舒张末期血流速度比值(PSV/EDV)升高,PI和RI升高,超声-生理学指标Dc和Cc减低,僵硬度的增加可作为诊断颈动脉粥样硬化较可靠指标。更多还原

【Abstract】 Objective To explore the feasibility of multi-index of ultrasound in diagnosing atherosclerosis(As) of carotid artery. Methods Forty-nine patients with As(atherosclerosis)of carotid artery considered as observed group(OG) and 35 normal subjects as control group(CG)were enrolled in the study. The indexes of hemodynamics, intima-media thickness(IMT) and ultrasound-physiology were compared between OG and CG. Results ① IMTs of both CCAs’ trunks and bifurcations in OG were significantly thicker than those in CG (P<0.01); ② Peak systolic velocity(PSV), end diastolic velocity(EDV) and mean velocity(MV) were decreased significantly in OG than those in CG(P<0.05); ③Both distensibility coefficient(Dc) and compliance coefficient(Cc) were decreased in OG but only Dc was decreased significantly(P<0.05); ④ IMTs of both CCAs’ trunks were of negative correlation with blood velocity and Dc but positive correlation with pulse pressure(PP), systolic pressure(SBP), systolic diameter(Ds), diastolic diameter(Dd) and wall stiffness(β) respectively. Conclusion The high-frequency ultrasonography of IMT of CCA is a precise way to evaluate As of carotid artery and the alteration of hemodynamics(such as decreased PSV, EDV, MV and increased PSV/EDV, PI, RI) and ultrasound-physiology (such as decreased Dc, Dd and increased β) are helpful indexes as well.更多还原