【摘要】 目的:探讨β-胡萝卜素(β-C)在急性出血坏死性胰腺炎(ANP)中对GSH及MDA影响。方法:Wistar大鼠随机分为3组:A组,ANP组;B组,β-C处理组;C组,假手术组,测定各组谷胱甘肽(GSH)、丙二醛(MDA)的变化。结果:同一时点比较发现:A组胰腺组织中GSH明显下降(P<0.05)、MDA明显升高(P<0.05);B组则GSH下降幅度较小,与A组比较差异有显著性(P<0.05),MDA升高幅度小,与A组比较差异有显著性(P<0.05)。结论:ANP时胰腺组织中内源性抗氧化物质GSH显著下降,MDA增加,β-胡萝卜素可作为氧自由基清除剂明显减轻ANP大鼠胰腺细胞损伤。更多还原

【Abstract】 Objective:To explore the influence of β-carotene on glutathione (GSH) and malonyl dialdehyde (MDA) in acute hemorrhagic necrosis of pancreas (AHNP). Method:Wistar rats were randomly divided into three groups:AHNP group;β-carotene group;control group.After AHNP rat models were made by using the Aho method,the levels of MDA and GSH were measured.Results:The GSH level in the AHNP group was remarkably decreased in acute hemorrhagic necrosis of pancreas(P<0.05),while MDA was significantly increased(P<0.05).The GSH level in the β-carotene group was higher than that in the AHNP group(P<0.05).The MDA level was lower than that in the AHNP group(P<0.05).And the histopathologic damage was attenuated to a certain extent.Endogenous anti-oxide GSH decreases remarkably in the pancreas in acute hemorrhagic necrosis of pancreas,MDA increases.Conclusion:β-carotene as ROS elimination agent reduce evidently the damage of rat pancreas cells.更多还原