【摘要】 该文系统归纳了蜂毒溶血肽的生物学功能,分子结构与性质,溶解血细胞的机理,以及溶血和抑菌活性与结构的关系,并结合本实验室研究着重综述了近年来国内外对蜂毒溶血肽作用机理的研究。提出今后研究应该向定量化方向发展,应用计算技术深入阐明蜂毒肽作用的动力学过程及结构与功能的关系,为今后指导分子设计打下一定的理论基础。更多还原

【Abstract】 We summarized progress in melittin, including the biological function, the molecular structure and characteristics, the mechanism of hemolysis and the relationship between the structure and the activity of hemolysis and antimicrobial of melittin. Meanwhile, based on the related research in our laboratory, we focused on the studies of the mechanism of melittin home and abroad in recent years. We proposed that the study on melittin should be quantified, and the calculation technology should be utilized for further illustrating the dynamical process of melittin and the relationship between structure and function, which may provide a firm theoretical basis for guiding molecular designing in future.更多还原