【摘要】 果蝇作为一种模式昆虫,为研究昆虫和人类的先天免疫发挥了重要作用。目前对果蝇体内免疫诱导产生的抗微生物肽多基因家族在分子进化、抗菌功能的分子特征和免疫诱导表达的信号传递机制等方面的研究进展,进一步加深了人们对昆虫乃至其他动物和人类先天免疫模式的认识,为研究其他昆虫特别是作为主要农林害虫的鳞翅目昆虫的先天免疫机制发挥了重要作用。本文集中对黑腹果蝇Drosophila melanogaster抗微生物肽及其免疫模式的研究结果和最新进展进行了介绍,其中包括作者近几年的研究结果。更多还原

【Abstract】 Drosophila melanogaster is an attractive model insect for dissecting the innate immunity system of invertebrates and vertebrates.The fruitful results on several aspects of antimicrobial peptides(AMPs),such as cloning and characterization of AMP genes,the signal transduction path way and the evolution of the AMPs multi-gene families in Drosophila species,have contributed a lot to the deep understanding of the innate immunity mechanism of insects and other organisms.Such results may also shed further light on the mechanism of immunity of some agricultural lepidopteran pest insects and the strategies of pest control.In this review,we summarized the structures,biological properties,the induction pattern,the signal transduction pathway,as well as the evolution of AMPs and their multi-gene families.更多还原