【摘要】 目的制备葛根素-聚乙二醇-6000(PEG6000)固体分散体以增加其溶出速率和溶解度。方法以PEG6000为载体,用熔融法制备固体分散体,并通过紫外光谱、红外光谱以及差示扫描量热法对固体分散体进行分析。结果以最佳工艺制备的葛根素固体分散体与葛根素原料药相比溶出速率提高了3倍,溶解度提高了17倍。紫外光谱、红外光谱和差示扫描量热法结果表明葛根素与PEG6000之间没有新的物相产生。结论葛根素-PEG6000固体分散体能极显著地提高葛根素的溶出速率和溶解度。更多还原

【Abstract】 Objective To prepare solid dispersions of puerarin with polyethylene glycol 6000 (PEG6000) to improve its dissolution and solubility. Methods The solid dispersions of puerarin were prepared by the fusion method with PEG6000 as the carrier. Evaluation of the properties of the dispersions was performed using dissolution studies, ultraviolet spectroscopy (UV), infrared spectroscopy (IR) and differential scanning calorimetery (DSC). Results The rate of dissolution and the solubility of puerarin in the solid dispersions prepared by the optimized preparing process were incresced 3 times and 17 times respectively as compared with crude puerarin. The data of UV, IR and DSC showed the absence of well-defined drugpolymer interactions. Conclusion The dissolution and solubility of puerarin could be improved significantly in solid dispersions with PEG6000.更多还原