【摘要】 目的研究肾上腺素采用电脑微量注射泵持续给药对室颤兔血流动力学的影响。方法采用开胸心外膜下电刺激法制备室颤动物模型,将实验兔20只随机分成2组,分别为肾上腺素持续给药组与间断给药组,测主动脉收缩压(ASP)、主动脉舒张压(AOD)、平均动脉压(MAP)、中心静脉压(CVP)、颅内压(ICP),计算冠状动脉灌注压(CoPP)、脑灌注压(CePP)及观察两组对室颤兔自主循环恢复(ROSC)率的影响。结果两组CePP差异有显著性(P<0.05),两组CoPP和ROSC率差异无显著性意义(P>0.05)。结论肾上腺素持续给药能维持更持久且高的脑灌注压,保证稳定的血流动力学。采用电脑微量泵持续给药是肾上腺素理想的给药方式。更多还原

【Abstract】 Objective To study the effects of continuously administered epinephrine with computer micro pump, on hemodynamic variation during experimental cardiopulmonary resuscitation (CPR).Methods Ventricular fibrillation was induced with epicardium electric current shock in 20 anaesthetised rabbits. The animals were randomized into two groups. One group received three boluses of adrenaline. The other group received an initial bolus of adrenaline followed by an infusion of adrenaline. Aortic systolic pressure(ASP) ,aortic diastolic pressure (AOD),mean arterial pressure(MAP),central venous pressure(CVP),intracranial pressure(ICP) were measured. coronary perfusion pressure(CoPP), cerebral perfusion pressure(CePP),restoration of spontaneous circulation (ROSC) were calculated.Results The data were analyzed with SPSS statistical software. During CPR cerebral perfusion pressure was higher (P<0.05) with a continuous adrenaline infusion than with repeated bolus doses. No differences in CoPP , rate of ROSC, were seen between the study groups.Conclusion Continuous infusion of adrenaline may generate a more sustained increase in CePP during CPR as compared to intermittent bolus doses. Thus, continuous infusion might be a more appropriate way to administer adrenaline as compared to bolus doses during CPR.更多还原