【摘要】 以3,4-二氟硝基苯与吗啉为原料合成了噁唑烷酮类抗菌药Linezolid中间体3-氟-4-吗啉硝基苯。考察了原料用量、反应温度、反应时间等因素对产物收率的影响,确定的最佳工艺条件为:n（3,4-二氟硝基苯）:n （吗啉）:n（无水Na₂CO₃）=1:1.4:0.052,反应温度78℃,反应时间6 h,收率大于98%,纯度大于99.5%。用UV-Vis,IR,¹H NMR,元素分析对产物进行了表征。更多还原

【Abstract】 3-Fluoro-4-morpholine-nitrobenzene,the intermediate for linezolid,was synthesized using morpholine and 3,4-difluoro-nitrobenzene.Under the optimal conditions,i.e.,n(3,4-difluoro-nitro- benzene):n(morpholine):n(sodium carbonate)=1:1.4:0.052,reaction temperature 78℃, and reaction time 6 h,the yield was above 98% with purity 99.5%.The product was characterized by UV-Vis,IR,~1H NMR and elemental analysis.更多还原