【摘要】 目的探讨急性期精神分裂症返回抑制时间进程的基本属性。方法30例健康志愿者及41例符合ICD-10精神分裂症诊断标准的急性期患者分别接受线索-靶子实验。靶子位置的2个水平分别为线索化位置和非线索化位置。线索开始呈现到靶子开始呈现的时间间隔(stimulus onsetasynchrony,SOA)的9个水平分别为300ms,400ms,500ms,600ms,700ms,800ms,1200ms,1500ms和2500ms。记录被试的反应时和错误率。结果(1)经重复测量方差分析,发现分组因素的主效应显著(P=0.000),健康对照组的平均反应时(365ms)短于精神分裂症患者的平均反应时(521ms)。靶子位置的主效应显著(P=0.000),靶子在线索化位置的反应时(458ms)长于非线索化位置的反应时(428ms)。SOA主效应不显著(P=0.338)。分组和SOA之间、分组和靶子位置之间、SOA和靶子位置之间以及分组、SOA和靶子位置之间的交互作用均不显著(P均>0.05)。(2)健康对照组在所有SOA水平上靶子在线索化位置的反应时均长于非线索化位置的反应时,差异均达非常显著性(P均<0.01)。(3)精神分裂症患者在所有SOA水平上靶子在线索化位置的反应时均长于非线索化位置的反应时,其中SOA为400ms,700ms和2500ms时,差异有显著性(P<0.05);SOA为600ms,800ms,1200ms和1500ms时,差异有非常显著性(P<0.01);而SOA为300ms和500ms时,差异无显著性(P>0.05)。结论正常人自SOA300ms以后就出现稳定的返回抑制,而急性期精神分裂症患者的返回抑制延迟出现,SOA600ms以后出现稳定的返回抑制。更多还原

【Abstract】 Objective:To explore the time course of inhibition of return(IOR)in acute schizophrenia.Methods:Thirty healthy volunteers and forty-one acute,drug-naive patients met with the 10th edition of International Classification of Disease criteria for schizophrenia were enrolled and completed the standard IOR task.During the double-cued condition,the target was present with equal probability in cued or uncued location,and nine different intervals corresponding to stimulus onset asynchronies(SOAs)of 300ms,400ms,500ms,600ms,700ms,800ms,1200ms,1500ms and 2500ms.Participants were told to push the space key correctly and their performance were recorded.Results:The mean reaction time(RT)to targets in normal control and schizophrenic group were 365ms and 521ms consecutively,RT for true cues and false cues were 458ms and 428ms,and their differences were both very significant(P=0.000).With paired t test,the IOR effect were indicated at all SOA levels in normal control,and schizophrenic group show the IOR effect just at SOA 400ms,600ms,700ms,800ms,1200ms,1500ms and 2500ms(P<0.05 or P<0.01),and deficit IOR effect were indicated at SOA 300ms and 500ms(P>0.05).However,the two-way or three-way interactions among cue type,SOA and group were all proved to be less significant(P>0.05).Conclusion:Delayed onset of inhibition of return exists in acute schizophrenia,and the IOR effect occur at SOA 600ms.更多还原