【摘要】 目的探讨中国汉族人口中儿茶酚胺氧位甲基转移酶(COMT)基因Val108/158Met多态性与伴迟发性运动障碍(TD)的精神分裂症患者认知功能的关系。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术对82例伴TD的精神分裂症患者COMT基因多态性进行检测,并选用连线测验(TMT)、韦氏记忆测验(WMS)、威斯康星卡片分类测验(WCST)对其认知功能进行评定。结果(1)COMT基因与TMT成绩显著相关,其中高活性G/G基因型PartA成绩显著低于中等活性G/A基因型,PartB成绩也显著低于低活性A/A基因型及中等活性G/A基因型。(2)COMT基因与记忆商数、背数成绩显著相关,其中G/G基因型记忆商数分显著低于A/A及G/A基因型,背数分也显著低于A/A基因型。(3)COMT基因与WCST成绩无显著相关性。结论COMT基因与伴TD的精神分裂症患者认知功能具有显著相关性,其中高活性G/G基因型患者认知损害更明显。更多还原

【Abstract】 Objective:To explore the relationship between catechol-O-methyltrans-ferase(COMT)gene Val108/158Met polymorphism and cognitive function in schizophrenic patients with tardive dyskinesia(TD)in Chinese Han people.Methods:82 schizophrenic patients with TD were studied using polymerase chain reaction(PCR)and restrictionfragment length polymorphism(RFLP)technique and 3 neuropsychological tests including Trail-Making Test(TMT)、Wechsler Memory Scale(WMS)and Wisconsin Card Sorting Test(WCST).Results:(1)COMT gene was associated with TMT performance.High activity genotype G/G had lower scores than middle activity genotype G/A in PartA and low activity genotype A/A and G/A in PartB.(2)COMT gene was related to Memory Quotient(MQ)and digit recite.Genotype G/G had lower scores than genotype G/A and genotype A/A in MQ as well as genotype A/A in digit recite.(3)COMT gene had no association with WCST performance.Conclusion:The Val108/158Met polymorphism of COMT gene is associated with cognitive function in schizophrenic patients with TD,and patients with high activity genotype G/G have significant cognitive impairment.更多还原