【摘要】 目的比较氯硝西泮、氟哌啶醇及其联合治疗对精神分裂症激越症状的疗效及安全性。方法本研究为随机、双盲、双模拟、平行活性对照研究,共分3组。氯硝西泮组15例,剂量范围(2~6)?/d;氟哌啶醇组15例,剂量范围(5~15)?/d;氟哌啶醇+氯硝西泮组15例,氯硝西泮剂量范围(2~6)?/d,氟哌啶醇剂量范围(5~15)?/d。3组均以简明精神症状评定量表(BPRS)总分、BPRS兴奋激越项目分数、BPRS阳性症状项目分数及按临床疗效总评量表(CGI)标准评定观察24小时。结果3组的总体疗效大致相当,24h治疗后BPRS兴奋激越项目评分与基线分比较均具显著性差异(P<0.01),但各组之间无显著性差异(P>0.05);BPRS阳性症状项目评分与基线分比较均无显著性差异(P>0.05),各组之间也无显著性差异。结论氯硝西泮肌注对精神分裂症兴奋激越症状的疗效与氟哌啶醇或氟哌啶醇加氯硝西泮相当。更多还原

【Abstract】 Objective: To compare the efficacy and safety of clonazepam, haloperidol and haloperidol combined with clonazepam in the treatment of the acute phase schizophrenia. Methods: 15 cases were treated with clonazepam with the dose of (2~6)㎎/d,15 cases were treated with haloperidol at the dose of (5~15)㎎/d , 15 cases were treated with clonazepam(2~6)㎎/d and haloperidol (5~15)㎎/d.Brief Psychiatric Rating Scale(BPRS) and Clinical Global Impression(CGI) were used to measure the efficacy and safety for 24 hours. Results:The efficacy of three groups in treating the acute phase schizophrenia was similar. Acute agitation in schizophrenia was significantly alleviated in each group(P〈0.01). Conclusions:Clonazepam was as efficacious as haloperidol and clonazepam combined with haloperidol in controlling excitement and agitation in schizophrenia patients.更多还原