【摘要】 目的探讨中国汉族青少年抑郁症与5-羟色胺转运体(5-HTT)基因的启动子区多态(5-HTTLPR)之间的关系。方法应用聚合酶链式反应(PCR)扩增技术对84例青少年抑郁症患者和85例健康者进行基因型分析。结果5-HTTLPR基因的3种基因型S/S,L/S和L/L在青少年抑郁症组的分布分别为57.1%,36.9%,6.0%;在对照组分别为57.6%,34.1%,8.2%,两组间差异无显著性(P>0.05)。抑郁症组中S/S基因型患者HAMD自杀因子评分明显高于L/L和L/S型患者(P<0.01)。结论5-HTT基因多态性与青少年抑郁症无明显关联。抑郁症中携带S/S基因型患者的自杀风险相对比L/L型、L/S型患者高。更多还原

【Abstract】 Objective: To explore the association between polymorphism of serotonin transporter gene and major depressive disorder(MDD) in adolescent.Methods: Altogether 84 MDD patients and 85 healthy controls were included in this study.The subjects were genotyped directly with polymerase chain reaction amplification fragment length polymorphism techniques.Results:The difference of genotypes and alleles of 5-HTTLPR between two groups was not significant(P>0.05).The difference of genotypes and alleles of 5-HTTLPR between suicide behavior and major depression disorder in adolescent was not significant(P>0.05).The scores of suicide-item of HAMD of patients with S/S genotypes were significantly higher than those of patients with L/L and L/S genotypes in MDD group(P<0.01).Conclusion:The association between the polymorphisms of 5-HTTLPR and adolescent depression was not significant.The results imply that the depression patients with S/S genotypes are at higher risk of suicide than the patients with L/S or L/S genotypes.更多还原