【摘要】 目的探讨CT引导下经皮穿刺植入放射性125I粒子与紫杉醇、顺铂化疗(TP)方案治疗非小细胞肺癌的临床价值。方法32例非小细胞肺癌患者在CT引导下进行125I粒子植入,手术后第1天给予紫杉醇135mg/m2;第2～4天,顺铂75mg/m2,28d为一个周期,化疗4个周期。125I粒子植入后1、3、6、12个月复查CT观察疗效。结果术后1个月复查CT,所有病灶均得到有效的控制,术后3、6、12个月肿瘤治疗有效率(CR+PR)分别为:87.5%、90.63%、92.31%。所有患者未出现放射损伤症状,未发现粒子迁移,化疗不良反应较轻。结论CT引导下经皮穿刺放射性125I粒子组织间照射并TP方案治疗非小细胞肺癌,是一种安全、有效的治疗方法,具有临床应用价值。更多还原

【Abstract】 Objective To discuss the clinical value of CT-guided percutaneous embedding of 125I seeds in combined chemotherapy with TP regime for non-small cell lung cancer(NSCLC). Methods Thirty two patients with NSCLC received CT-guided percutancous embedding of 125I particles, TP chemotherapy plan (paclitaxcl 135 mg/m2 /d1, cisplatin 75 mg/m2/d2 ～ 4 ) for four cycles after operation. The follow-up CT for observing therapeutic effects at 1, 3, 6, 12 month after 125I seeds implantation was undertaken. Results All cases were controlled effectively after one month revealed by CT follow up. The efficiency of tumor curing at 3, 6, 12 month were 87.5%, 90.63%, 92.31% respectively. None of the patients showed radiation injury and particle migration, and all of them had only slight side effects. Conclusion CT-guided percutaneous embedding of 125I seeds in combination with chemotherapy for non-small cell lung cancer is an effective and safe method, possessing valuable utilization clinically.更多还原