【摘要】 目的研究广西壮族人群4个STR(short tandem repeats)基因座:D6S477、D18S865、D19S400、D20S161的遗传多态性。方法应用PCR扩增结合聚丙烯酰胺凝胶电泳技术分析200名广西壮族无关个体。结果4个STR基因座平均期望杂合度为0.8442,平均多态信息总量为0.8247,累积个体识别力达0.999994474,累积非父排除率达0.9856。D6S477的等位基因15、D18S865的等位基因10和11、D19S400的等位基因11、D20S161的等位基因18可能是广西壮族群体中相应STR基因座最原始的等位基因。结论广西壮族的4个STR基因座属高度遗传多态性。更多还原

【Abstract】 Objective To investigate the genetic polymorphisms for four short tandem repeats (STR) loci (D6S477,D18S865,D19S400,D20S161)in Zhuang Ethnic in Guangxi province.Methods 200 unrelated individuals were analyed using polymerase chain reaction technique combined with polyacrylamide gel electrophoresis. Results The average expected heterozygosity in the four STR loci was 0.8442, the average polymorphism information content was 0.8247,the accumulative discrimination power was 0.999994474 and the accumulative probability of paternity exclusion was 0.9856. Allele 15 in D6S477, allele 10 and 11 in D18S865, allele 12 in D19S400 ,18 in D20S161 was probably the most primitive allele in respective locus. Conclusion The data obtained possess highly genetic polymorphisms .更多还原