Objective To synthesize new organogermanium compounds with stronger cytotoxic activities,and study the relationship between the structure and anticancer activity.Methods Two novel organogermanium sesquioxides with quinoline moiety were synthesized by a new method.Cell growth inhibition was measured by the MTT method.PC-3M prostate cancer cell line was treated with newly synthesized compounds.at 10 μm,30 μm and 60 μm,respectively.The experiments were repeated three times.Results The IC50 of compounds were l0...
【更新日期】
2007-05-16
【分类号】
R91;R96
【正文快照】
Of the physiologically active organogermaniumcompounds,Ge132and Ge132derivatives or analogshave been specially paid attention due to their rela-tively low toxicities and diversely biological activi-ties[1-4].It has been found that some of Ge-132derivative
| 
推荐 
点击下列相关研究机构和相关文献作者，可以直接查到这些机构和作者被《中国知识资源总库》收录的其它文献，使您全面了解该机构和该作者的研究动态和历史。
