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谷胱甘肽滴眼液与乃奇安治疗老年性白内障的随机对照研究

Randomized Controlled Study of The Anti-Cataract of Glutathione Ophthalmic Solution Compared with Neuthione in Patients with Senile Cataract

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【作者】 李新芳侯艳宁吴静安殷悦晏晓明韩秀娴吴众邹海兰姜凌力王磊峰黄秋闽

【Author】 LI Xin-Fang①,HOU Yan-Ning,WU Jing-An②,YIN Yue②,YAN Xiao-Ming②,HAN Xiu-Xian③,WU Zhong③,ZOU Hai-Lan④,JIANG Lin-Li④,WANG Lei-Feng④,HUANG Qiu-Min④(①National Base for Drug Clinical Trial,Bethune International Peace Hospital of PLA,Shijiazhuang 050082;Hebei China)(②Department of Ophthalmology,First Hospital,Beijing University,Beijing 100034 China)(③Institute of Ophthalmology,Henan Province,Zhengzhou 450003;Henan China)(④Department of Ophthalmology,General Hospital of Beijing Command,Beijing 100005 China)

【机构】 解放军白求恩国际和平医院国家药品临床研究基地北京大学第一医院眼科河南眼科研究所北京军区总医院眼科北京军区总医院眼科 河北石家庄050082北京100034河南郑州450003北京100005

【摘要】 目的评价国产谷胱甘肽滴眼液对老年性白内障的临床疗效及安全性。方法175例白内障患者以3/2的比例随机分为两组,分别点国产谷胱甘肽滴眼液或乃安奇1~2滴,tid,疗程6个月。结果国产谷胱甘肽滴眼液与乃安奇组的视力有明显的改善(P<0.01)两组的总有效率为分别48.57%和44.28%(P>0.05)。两组药物的不良反应轻微,发生率分别为19.05%、8.57%(P>0.05)。结论谷胱甘肽滴眼液是治疗老年性白内障安全、有效的药物。

【Abstract】 Aim To evaluate the safety and efficacy of domestic glutathione ophthalmic solution in the clinical treatment of patients with senile cataract.Methods 175 patients with senile cataract were selected and at a ratio of three to two randomly divided into the glutathione ophthalmic solution group and the neuthione group.Each of them,respectively,received treatment of domestic glutathione ophthalmic solution and neuthioe by instilling 1 to 2 drops in the eye 3 times daily,for 6 months.Results The eyesight of the glutathione ophthalmic solution group and neuthione group was significantly improved(P< 0.01).The clinical efficacy rate of glutathione ophthalmic solution and neuthione was 48.57% and 44.28%(P>0.05),respectively.The adverse drug reactions of both groups were mild at 19.05%,8.57%,respectively.Conclusion This results suggest that glutathione ophthalmic solution is a safe and effective anti-cataract drug.

  • 【文献出处】 解放军药学学报 ,Pharmaceutical Journal of Chinese People’s Liberation Army , 编辑部邮箱 ,2007年03期
  • 【分类号】R776.1
  • 【被引频次】8
  • 【下载频次】99
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