【摘要】 目的研究严重急性呼吸综合征(SARS)男性患者睾丸组织的病理变化。方法对5例SARS死亡患者的睾丸组织进行常规组织学、TUNEL及免疫组化染色。结果5例SARS患者睾丸生精小管基膜增厚、纤维化,生精上皮坏死、脱落,睾丸中几乎未见精子。生精细胞凋亡大量增加(P<0.05),间质充血,睾丸组织中有明显的白细胞浸润。CD3+T淋巴细胞、CD68+巨噬细胞较对照组明显增多(P<0.05),并浸润到生精小管中。结论SARS导致男性患者并发睾丸炎。更多还原

【Abstract】 Ojective To study the pathological changes of testis tissue in SARS patients.Methods Tissue specimens were studied by HE staining、TUNEL and immunohistochemistry(IHC).Results SARS patients showed that widespead germ cells destruction,few or no spermatozoon in the seminiferous epithelium and the lumen,thickened basement membrane、 peritubular fibrosis、 vascular congestion and leukocytes infiltration.The apoptotic seminiferous cells increased significantly(P<0.05).The numbers of CD3+T lymphocyte and CD68+ macrophage increased significantly in the interstitial tissue as compared with that of control group(P<0.05),and infiltration of both cell types was found in the tubules.Conclusion SARS caused orchitis.更多还原