【摘要】 目的研究抑郁症患者治疗前后认知功能改变及相关因素。方法对100例符合中国精神障碍分类与诊断标准的抑郁症患者(患者组),给与单一抗抑郁药治疗8周。于治疗基线和治疗末评定24项汉密尔顿抑郁量表(HAMD24)、威斯康星卡片分类测验(WCST)、中国韦氏成人记忆量表(WMS-RC)、连线A、B测验,并与100名健康志愿者(对照组)比较。结果(1)治疗后患者组的神经心理学测验成绩较治疗前均有明显提高(P<0.05或P<0.01)。(2)患者组WMS-RC中的数字广度(倒背)改变与睡眠障碍分改变呈负相关(r=-0.244,P=0.014);连线测验B的测验时间与认识障碍分呈负相关(r=-0.230,P=0.021),提笔数与绝望感分呈正相关(r=0.312,P=0.002);WCST中的分类数与认识障碍分(r=-0.197,P=0.049)、焦虑/躯体化分呈负相关(r=-0.225,P=0.024)。(3)痊愈组和症状残留组的WCST及WMS-RC检测均低于对照组(P<0.01和P<0.05)。结论抑郁症患者治疗后认知功能显著改善,与临床症状的缓解存在相关性,但仍与对照组存在统计学差异,这提示抑郁症患者认知功能损害特质性与状态性均存在。更多还原

【Abstract】 Objective To analyse the cognitive function in depression and the related factors before and after therapy.Methods 100 patients with depression were given one antidepressive for 8 weeks,and 100 healthy people were involved as controls.The depression severity was assessed with the 24-item Hamilton Depression Scale(HAMD24),and cognitive function with a series of neuropsychological tests including Wisconsin cards sorting test(WCST),Wechsler memory scale of Republic of China(WMS-RC),Trial test A and B.Results(1)the depressed patients made improvements in the neuropsychological tests after treatment(P<0.05 or P<0.01).(2)the improvement in number extent was negatively correlated to the alleviation in sleep disturbance symptom(r=-0.244,P=0.014),decrease of testing time in trial B negatively to the cognition item score of HAMD24.The scores of WCST categories negatively correlated to the reduction in cognition and anxiety/somatization.(3)Compared with controls,the recovered patients(with HAMD24 total score ≤8) and the patients with residual symptoms still have lower scores on the parameters of WCST and WMS-RC(P<0.01 or P<0.05).Conclusions The cognitive function in patients with depression improves after treatment,with correlation to the after depression symptoms remission and statistical difference with control group.更多还原