【摘要】 目的探讨血清半胱氨酸蛋白酶抑制剂C(Cystatin C)在早期糖尿病肾病的诊断价值。方法测定和比较糖尿病正常白蛋白尿组、糖尿病微量白蛋白尿组与正常人血清CystatinC的浓度。结果糖尿病正常白蛋白尿组(0.76±0.38mg/l)与正常对照组(0.70±0.32mg/l)比较无显著性差异(P>0.05);糖尿病微量白蛋白尿组(1.82±0.98mg/l)与糖尿病正常白蛋白尿组(0.76±0.38mg/l)(P<0.001)和正常对照组(0.70±0.32mg/l)比较有显著性差异(P<0.001)。结论血清CystatinC是糖尿病肾病早期诊断的理想指标。更多还原

【Abstract】 Objective To explore the diagnostic value of serum cystatin C in early stage diabetic nephropathy.Methods We measured and compared the serum cystatin C concentrations among the normal control group,the diabetic patient group with normal albumin excretion in urine,and the diabetic patient group with microalbuminuria.Results There were no significant differences in serum cystatin C levels between the diabetic patient group with normal albumin excretion in urine(0.76±0.38mg/l)and the normal control group(0.70±0.32mg/l)(P>0.05).The serum cystatin C concentration in the diabetic patient group with microalbuminuria(1.82±0.98mg/l)was significantly increased when compared with the diabetic patient group with normal albumin excretion in urine(0.76±0.38mg/l)and the normal control group(0.70±0.32mg/l)(P<0.001respectively).Conclusion Serum cystatin C is a sensitive eartly diagnostic marker for diabetic nephropathy.更多还原