【摘要】 目的探讨联合检测抗dsDNA、尿微量白蛋白、血细胞变化及D-二聚体对系统性红斑狼疮(SLE)的诊断价值。方法96例初诊SLE患者及36名健康体检者全血,用全自动血液细胞分析仪检测血细胞计数,用胶体金抗体免疫渗滤法检测血浆D-二聚体水平,用免疫散射比浊法检测尿微量白蛋白,用胶体金斑点渗滤法检测血清抗dsDNA抗体,并进行分析比较。结果SLE特异性指标抗dsDNA阳性率仅为42.7%,而血细胞异常率较高达70.8%,早期肾损害的指标尿微量白蛋白阳性率为65.6%,D-二聚体阳性率为58.3%;四者联合检测阳性率提高至90.6%。结论联合检测抗dsDNA、尿微量白蛋白、血细胞变化及D-二聚体对SLE的诊断具有重要意义,可提高对SLE的检测敏感性。更多还原

【Abstract】 Objective To evaluate the significance of combined determination of anti-dsDNA,urine microalbumin(MA),blood cells and D-dimer in the diagnosis of systemic lupus erythematosus(SLE).Methods In 96 cases of SLE and 36 cases of healthy people,serum anti-dsDNA and plasma D-dimer were detected by colloidal gold method,urine MA by immune dispersion scatter turbidity method and blood cells were counted by automatic blood cells analyzer.Results The positive rate of anti-dsDNA,low blood cells,urine MA,and D-dimer in patients with SLE was 42.7%,70.8%,65.6%,and 58.3% respectively,while after combined determination of anti-dsDNA,low blood cells,urine MA,and D-dimer,the positive rate was 90.6%.Conclusion The combined determination of anti-dsDNA,low blood cells,urine MA,and D-dimer may improve the sensitivity of laboratory diagnosis of SLE.更多还原