【摘要】 目的通过癌性恶病质动物模型探讨血清中胰岛素样生长因子-I(IGF-I)水平在癌性恶病质中的作用。方法将小鼠结肠腺癌26细胞悬液接种于肝脏特异性IGF-I基因缺失(LID)组鼠和对照组鼠皮下,各30只接受了肿瘤细胞接种。接种后监测两组小鼠的一般情况、体重和皮下肿瘤大小以及自然生存时间。结果LID鼠和对照鼠进入恶病质的时间分别为(14.6±1.3)d、(24.1±2.5)d;生存时间分别为(19.3±1.3)d、(31.9±2.7)d,两者差异有极显著性意义(P<0.01)。结论血清中低水平的IGF-I虽然可以延缓肿瘤的生长,但是却促进了癌性恶病质的发生和发展。更多还原

【Abstract】 Objective To explore the role of serum insulin-like growth factor-I(IGF-I) in experimental cancer cachectic animal model.Methods A suspension of murine colon 26 adenocarcinoma cells was inoculated subcutaneously into the control and liver-specific IGF-I deficient(LID) mice,respectively,n=30 in each group.General condition,body weight,tumor size and survival time were measured daily after inoculation in each group.Results There was significant difference in the time of cachectic condition and survival between the two groups (P<0.01).Median time of entering the cachectic condition in LID and control mice was (14.6±1.3)d and(24.1±2.5)d,and median survival time in LID and control mice were (19.3±1.3)d and(31.9±2.7)d,respectively.Conclusion Low level of IGF-I in sera could delay the progression of the tumor,but it promoted the onset and development of cancer cachexia.更多还原