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间尼索地平对KCl及ET-1所致离体家兔冠状动脉分支收缩的拮抗作用
Antagonistic effects of m-Nisoldipine on the contractile response of rabbit coronary artery rings induced by KCl and ET-1
【摘要】 目的研究间尼索地平(m-Nis)对KCl及ET-1所致离体家兔冠状动脉分支收缩的拮抗作用。方法通过Myograph System-610M描记离体家兔冠状动脉环的张力变化。结果m-Nis和Nis几乎可以完全抑制70 mmol.L-1KCl诱发的离体家兔冠状动脉分支收缩,且均有浓度依赖性,m-Nis的作用比Nis更强;不同浓度的m-Nis(1×10-5、1×10-6、1×10-8、1×10-10mol.L-1)均可以抑制ET-1引起的离体家兔冠状动脉分支收缩;m-Nis使ET-1收缩冠状动脉的效能和效价均降低,随着剂量的增大,抑制作用增强。结论m-Nis对KCl及ET-1诱发的家兔冠状动脉分支收缩均有良好的抑制效果。
【Abstract】 OBJECTIVE To study the effects of m-Nisoldipine(m-Nis) on KCl and ET-1 induced contractile responses in rabbit coronary artery smooth muscle.METHODS The tension of rabbit coronary artery rings was measured by Myograph System-610M.RESULTS m-Nis and Nis could completely antagonize the contractile responses of isolated rabbit coronary artery branch induced by 70 mmol·L-1 KCl in a concentration dependent manner.The antagonistic effect of m-Nis was stronger than that of Nis.Different concentration of m-Nis(1×10-5,1×10-6,1×10-8,1×10-10 mol·L-1) could antagonize the contractile responses of isolated rabbit coronary artery branch induced by ET-1 and reduce both efficacy and potency of ET-1.CONCLUSION m-Nis antagonizes the contraction responses of rabbit coronary artery smooth muscle induced by KCl and ET-1.
【Key words】 Variant angina; m-Nisoldipine; Nisoldipine; Coronary artery; KCl; ET-1;
- 【文献出处】 华西药学杂志 ,West China Journal of Pharmaceutical Sciences , 编辑部邮箱 ,2007年01期
- 【分类号】R965
- 【被引频次】6
- 【下载频次】72