【摘要】 目的观察辛伐他汀对高肺血流并野百合碱注射大鼠肺动脉高压模型的影响。方法采用腹主动脉-下腔静脉造瘘联合野百合碱注射制作肺动脉高压动物模型。40只大鼠随机平均分为安慰剂组、辛伐他汀A组〔1mg/(kg·d)〕、辛伐他汀B组〔2mg/(kg·d)〕和正常对照组。造瘘术后第37d各组分别测量平均肺动脉压力(mPAP)和右心室肥厚程度〔RV/(LV+S)〕,观察肺小动脉血管厚度,比较无肌性动脉肌化程度,比较血清总胆固醇(CHOL)浓度。结果同正常对照组相比,安慰剂组大鼠的mPAP〔(24.6±3.2)vs(13.9±1.4)mmHg,1mmHg=0.133kPa〕、RV/(LV+S)〔(0.456±0.071)vs(0.245±0.026)〕升高(P<0.05),肺小动脉血管厚度增加〔(28.64±5.95)%vs(9.36±2.24)%,P<0.05〕,无肌性血管肌化百分比增加〔(66.25±9.32)%vs(17.67±3.62)%,P<0.05)〕。辛伐他汀治疗减轻了安慰剂组各项指标的增加(P<0.05)。各组间血清CHOL浓度差异无统计学意义。结论辛伐他汀通过抑制大鼠肺小血管重构,减轻肺动脉高压的形成,提示辛伐他汀可能对左向右分流型先心病具有一定的治疗前景。更多还原

【Abstract】 Objective To explore the therapeutic effect of simvastatin on the pulmonary hypertension induced by injected monocrotaline combining with high pulmonary blood flow of rats. Methods Forty male SD rats were randomly divided into the placebo group, simvastatin 1 mg/(kg·d) group, simvastatin 2 mg/(kg·d) group and control group. The arterial-venous shunt rats were injected with monocrotaline at day 7 and developing the pulmonary hypertension after shunting operation. Rats were received either placebo or treatment with simvastatin in the respective group. On day 37 after the shunt operation, the mean pulmonary artery pressure (mPAP) and right ventricular hypertrophy right ventricle/(left ventricle+septum), RV/(LV+S) of all rats were measured. The percent vascular wall thickness and muscularization of the pulmonary small arteries were evaluated. The blood samples were collected to compare the total cholesterol levels between groups. Results The RV/(LV+S) and mPAP elevated obviously in placebo group compared to the control group (P<0.05). The muscularization of pulmonary small arteries and pulmonary artery medial hypertrophy increased significantly in placebo group compared with the control group (P<0.05). The simvastatin treatment made the attenuation of the above-mentioned indexes in this animal model (P<0.05). There was no significant statistics difference of the total cholesterol levels between any two groups (P>0.05). Conclusion By inhibiting the pulmonary vascular remodeling, simvastatin attenuated the development of pulmonary hypertension. Simvastatin may have preventive and therapeutic effects on pulmonary hypertension.更多还原