【摘要】 在弱碱性的多聚磷酸钠介质中,二价铜离子、过氧化氢和染料罗丹明B混合可以产生较强的化学发光,西咪替丁对此发光有较强的抑制作用,其抑制发光强度与西咪替丁P43的质量浓度在5.0-1000μg.L-1范围内呈良好的线性关系,基于此,结合流动注射技术,建立了一种直接测定西咪替丁的化学发展发光新方法。该方法具有较高的灵敏度,检出限为2.2μg.L-1(IUPAC),对500μg.L-1西咪替丁平行测定11次,其相对标准偏差为2.1%。该方法已成功用于西咪替丁胶囊和针剂含量的测定。更多还原

【Abstract】 A new flow injection chemiluminescence（FI-CL） system for determination of cimetidine is presented.In sodium polyphosphate medium,hydroxyl radical could be generated by the reaction of Cu²⁺with H₂O₂and the hydroxyl radical could oxidize rhodamine B to produce CL.Cimetidine could decrease the CL intensity The decreased CL intensity was linear with the cimetidine concentration in the range of 5.0-1000μg/L.The detection limit was 2.2μg/L and the relative standard deviation（RSD） for determination of 500μg/L cimetidine was 2.1%（n=11）.The mechanism of the novel CL system was also discussed.The proposed method had been successfully applied to the determination of cimetidine in campsules and injections.更多还原