【摘要】 采用Gattermann-Koch反应合成了2,4,6-三甲基苯甲醛,并优化了合成的工艺条件。探讨了反应温度、CO压力、浓盐酸用量及助催化剂的影响。最佳工艺条件为:当均三甲苯用量为200.0 g时,均三甲苯与无水AlCl3摩尔比为3.08,反应温度26~28℃,CO压力1.06~1.48 MPa,AlCl3与浓盐酸质量比为550,AlCl3与TiCl4的质量比为45,反应20 h,收率86.86%。添加助催化剂TiCl4可以提高收率,溶剂乙醚的加入能大幅度地减少反应时间。更多还原

【Abstract】 2,4,6-trimethylbenzaldehyde was synthesized through Gattermann-Koch reaction,and the reaction condition was optimized.The effects of reaction temperature,pressure of carbon monoxide,the amount of hydrochloric acid,and the promoter were discussed.The reaction can be promoted by titanium（Ⅳ） chloride（TiCl₄） and ethyl ether.The optimized condition is:the molar ratio of 2,4,6-trimethylbenzaldehyde to anhydros aluminum chloride（AlCl₃） is 3.08,molar ratio of AlCl₃ to concentrated aqueous hydrochloride is 550,weight ratio of anhydros AlCl₃ to TiCl₄ is 45,pressure of carbon monoxide is 1.06—1.48 MPa,at 26—（28 ℃）,for 20 h,yield of 86.86%.更多还原