【摘要】 目的:探讨丙氨酰-谷氨酰胺(Ala-Gln)对重型颅脑损伤患者免疫功能的影响,为临床治疗提供理论依据。方法:选取重型颅脑损伤病例75例,随机分为两组。Ala-Gln组(n=36)为Ala-Gln干预治疗,入院抽血后每日静脉滴注Ala-Gln 0.40 g/(kg.d),连续使用15 d;常规组(n=39)不用Ala-Gln。两组均于入院第1天、第3天、第7天、第15天采血检测患者T细胞亚群(CD3、CD4、CD8、CD4/CD8),免疫球蛋白(IgAI、gG、IgM)水平。结果:Ala-Gln组与常规组相比,CD3、CD4细胞比例,CD4/CD8比值及IgGI、gA明显升高,且改善时间更早。结论:肠外补充Ala-Gln有助于改善重型颅脑损伤患者免疫功能。更多还原

【Abstract】 Objective: To investigate the effects of Alanine-Glutamine(Ala-Gln) on immune function in patients with severe craniocerebral trauma.Methods: Seventy five cases of severe craniocerebral trauma were randomized divided into two groups: intervening group(36 cases) given Ala-Gln injection for 15 days 0.4g/kg/day,conventional group(39 cases) treated with routine.Serum level of T lymphatic cells,including CD3,CD4,CD8 and CD4/CD8 ratio,immunoglobulin,including IgA,IgG and IgM were detected at day1(before injection),day3,day7 and day15,respectively in two groups.Results: Counts of CD3,CD4 and CD4/CD8 ratio,serum IgG,IgA increased distinctly and improved early in intervening group than that in conventional group.Conclusion: Ala-Gln is effective on improving immune function in patients with severe craniocerebral trauma.更多还原