【摘要】 目的:探讨多囊卵巢综合征(polycystic ovary syndrome,PCOS)最佳实验诊断指标的筛选及高雄激素血症的形成机制。方法:PCOS组:持续无排卵,高雄激素,高雄激素的临床特征,排除其它病因。年龄16～35(28.13±2.25)岁。正常对照组:月经周期规律、排卵功能及内分泌功能正常。年龄15～37(27.32±3.21)岁。按体重指数(body mass index,BMI;kg/m2)进行分组。PCOS组:PCOSⅠ组为BMI<25 kg/m2;PCOSⅡ组为BMI 25～29 kg/m2;PCOSⅢ组为BMI>30 kg/m2。正常对照组:对照Ⅰ组为BMI<25 kg/m2;对照Ⅱ组BMI≥25 kg/m2。均于卵泡早期(月经第2～4天)检测患者血清中LH、FSH、E2、PRL、T、PDGF、EGF、LEP、脂联素、血糖和胰岛素水平。结果:PCOS组的LH、FSH、E2、PRL、T、LEP、脂联素、血糖和胰岛素水平与对照组比较,差异有统计学意义(P<0.05)。结论:筛选并建立了较佳的检验程序和指标;LH、FSH、E2、PRL、T、LEP、脂联素、血糖和胰岛素水平与PCOS的发生有关。更多还原

【Abstract】 Objective: To screen the pragmatic indexes for polycystic ovary syndrome(PCOS) and explore the mechanism of hyperandrogen.Methods: PCOS group: anovulation,hyperandrogen,clinical syndromes related to hyperandrogen,removing other diseases.Age range from 16 to 35 years(28.13±2.25).Normal group: regular menstrual cycle,normal ovulation and endocrine secretion,normal ovary.Age range from 15 to 37 years(27.32±3.21).PCOS patients were classified as PCOSⅠ(BMI<25 kg/m2),PCOSⅡ(BMI25~29 kg/ m2),PCOS Ⅲ(BMI>30 kg/ m2),control group was divided into 2 groups as normal Ⅰ(BMI<25 kg/m2)and normalⅡ(BMI≥25 kg/m2)groups randomly by body mass index(BMI),respectively.Serum LH,FSH,E2, PRL,T,PDGF,EGF、LEP、Adiponectin、Glucose 、Insulin was measured in early antral follicle(on day 2-4 of menstrual cycle).Results: There were significant differences between PCOS and normal group in above LH,FSH,E2,PRL,T,LEP、Adiponectin、Glucose、Insulin(P<0.05).Conclusion: Screen and set up better laboratory process and indexes;LH、FSH、E2、PRL、T、LEP、Adiponectin、Glucose、Insulin may be related with the onset of PCOS.更多还原